Sigma receptor ligands and the use thereof

Details Sigma receptor ligands and the use thereof Sigma receptor ligands and the use thereof

C - Chemistry, Metallurgy

07

C

C07C 211/26 (2006.01) A61K 31/135 (2006.01) A61K 31/215 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07C 211/08 (2006.01) C07C 211/17 (2006.01) C07C 211/27 (2006.01) C07C 211/28 (2006.01) C07C 211/29 (2006.01) C07C 211/30 (2006.01) C07C 211/42 (2006.01) C07C 215/52 (2006.01) C07C 215/54 (2006.01) C07C 217/16 (2006.01) C07C 217/60 (2006.01) C07C 219/

Patent

CA 2111957

2111957 9300313 PCTABS00019 The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.

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