Use of combination of anti-angiogenic substance and c-kit...

Details Use of combination of anti-angiogenic substance and c-kit... Use of combination of anti-angiogenic substance and c-kit...

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/404 (2006.01) A61K 31/4409 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/502 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 215/48 (2006.01)

Patent

CA 2627598

Disclosed are: a pharmaceutical composition having an excellent anti-tumor effect; and a therapeutic method for cancer. 4-(3-Chloro-4- (cyclopropylaminocarbonyl)aminophenoxy)-7 -methoxy-6-quinolinecarboxamide or an analogue thereof can be used in combination with a substance having a c-kit kinase-inhibiting activity to produce an excellent anti-tumor effect.

L'invention concerne une composition pharmaceutique présentant un excellent effet antitumoral; ainsi qu'une méthode de traitement du cancer. L'invention concerne plus spécifiquement du 4-(3-chloro-4-(cyclopropylaminocarbonyl) aminophénoxy) -7-méthoxy-6-quinolinecarboxamide ou un analogue de ce dernier pouvant être utilisé en combinaison avec une substance présentant une activité inhibitrice de kinase c-kit afin de produire un excellent effet antitumoral.

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