Expression and processing of authentic fgf's in yeast

Details Expression and processing of authentic fgf's in yeast Expression and processing of authentic fgf's in yeast

C - Chemistry, Metallurgy

12

N

530/13, 195/1.2,

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C12N 1/19 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2002210

Methods and compositions are provided for producing, in yeast, basic and acidic fibroblast growth factors (FGF's) that are at least partially acetylated at their amino-termini. DNA constructs containing genes coding for the FGF polypeptides under transcriptional control of a regulatable promoter are expressed in transformed host yeast cells to achieve high yields of the processed FGF'S,

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