Treatment of apolipoprotein-a1 related diseases by...

Details Treatment of apolipoprotein-a1 related diseases by... Treatment of apolipoprotein-a1 related diseases by...

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2739464

Oligonucleotide compounds modulate expression and/or function of an apolipoprotein (ApoA1) polynucleotides and encoded products thereof. Methods for treating diseases associated with apolipoprotein- A1 (ApoA1) comprise administering one or more Oligonucleotide compounds designed to inhibit the Apo-A1 natural antisense transcript to patients.

L'invention concerne des composés d'oligonucléotides qui modulent l'expression et/ou la fonction de polynucléotides d'une apolipoprotéine (ApoA1) et des produits codés de ceux-ci; des méthodes de traitement de maladies liées à l'apolipoprotéine Al (ApoA1), qui comprennent l'administration à des patients d'un ou de plusieurs composés d'oligonucléotides conçus pour inhiber le produit de la transcription de l'ApoA1 antisens naturel.

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