C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 38/00 (2006.01) A61K 39/21 (2006.01) A61K 39/395 (2006.01) A61K 39/42 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2498483
A method for preventing infection of helper T and other target cells by human immunodeficiency virus type 1 ("HIV-1") and for preventing or treating acquired immunodeficiency syndrome ("AIDS") by exposing target cells to a synergistic combination of at least one attachment inhibitor and at least one fusion inhibitor. The attachment inhibitors are compounds that bind to the CD4 receptor on target cells or that bind to gp120 on HIV-1, e.g., antibodies, and the fusion inhibitors compounds that interact with gp4l to inhibit or prevent its interaction with target cells, e.g., pentafuside.
méthode de prévention de l'infection des lymphocytes T auxiliaires et autre cellules cibles par le virus de l'immunodéficience humaine de type 1("VIH-1") et de prévention ou de traitement du syndrome d'immunodéficience acquise ("SIDA"), consistant à exposer des cellules cibles à une combinaison synergétique d'au moins un inhibiteur de fixation et d'au moins un inhibiteur de fusion. Les inhibiteurs de fixation sont des composés qui se lient au récepteur CD4 sur les cellules cibles ou à gp120 sur le HIV-1, c'est-à-dire des anticorps, et les inhibiteurs de fusion des composés qui interagissent avec gp4l pour inhiber ou empêcher son interaction avec des cellules cibles, tels que le pentafuside.
Genentech Inc.
Sim & Mcburney
Tanox Inc.
LandOfFree
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