C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/39 (2006.01) C07K 14/78 (2006.01)
Patent
CA 2271935
The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the .beta.-subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.
La présente invention décrit une interaction directe entre la myosine et le domaine cytoplasmique de protéines membranaires, en particulier les domaines cytoplasmiques phosphorylés de la sous-unité .beta. d'intégrines. L'invention concerne des méthodes d'identification d'agents bloquant la liaison d'intégrine à la myosine; des méthodes d'utilisation d'agents bloquant la liaison d'intégrine à la myosine afin de moduler des procédés biologiques et pathologiques; et des agents bloquant la liaison assistée d'intégrine à la myosine, modulant ainsi le déplacement associé d'une cellule ou d'un composant cellulaire.
Jenkins Alison L.
Phillips David R.
Cor Therapeutics Inc.
Deeth Williams Wall Llp
Millennium Pharmaceuticals Inc.
LandOfFree
Modulation of interactions between myosin and integrins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulation of interactions between myosin and integrins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of interactions between myosin and integrins will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1505054