C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/506 (2006.01) A61K 31/5383 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2755810
The present invention relates to a compound of Formula (I): wherein: n is 0 or 1; X is O or CH2; R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10 R5 is H or OCH3; R10 is F or Cl; or a pharmaceutically acceptable salt or ester thereof.
La présente invention concerne un composé de formule (I) : dans laquelle : n représente 0 ou 1 ; X représente O ou CH2 ; R1 représente H ou un alkyle en C1 à C2 ; R2 représente H ou un alkyle en C1 à C3 ; R3 et R4 représentent chacun indépendamment H ou un alkyle en C1 à C2, l'alkyle pouvant être substitué par un à trois substituants identiques ou différents choisis parmi R10 ; R5 représente H ou OCH3 ; R10 représente F ou Cl ; ou un sel ou un ester pharmaceutiquement acceptable de celui-ci.
Iwama Toshiharu
Kawanishi Nobuhiko
Mortimore Michael
Ohkubo Mitsuru
Sunami Tomoko
Msd K.k.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Vertex Pharmaceuticals Incorporated
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