N-substituted azaheterocyclic compounds

Details N-substituted azaheterocyclic compounds N-substituted azaheterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) C07D 211/60 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2267500

The present invention relates to novel N-substituted azaheterocyclic compounds of general formula (I), wherein X, Y, Z, A, R1, R2, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.

L'invention concerne des composés azahétérocycliques N-substitués nouveaux, représentés par la formule générale (I), dans laquelle X, Y, Z, R?1¿, R?2¿, r et s sont tels que définis dans la partie détaillée de la description, ou des sels desdits composés. L'invention concerne également des procédés de fabrication desdits composés, des compositions les renfermant et l'utilisation desdits composés dans le traitement clinique d'états douloureux, hyperalgésiques et/ou inflammatoires, dans lesquels des fibres C jouent un rôle pathophysiologique en déclenchant une douleur ou une inflammation neurogènes. L'invention concerne enfin l'utilisation desdits composés dans le traitement d'indications qui sont causées par la sécrétion et la circulation de peptides antagonistes de l'insuline ou qui sont liées.

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