Stable formulation comprising moisture sensitive drug/s and...

A - Human Necessities – 61 – K

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Details

A61K 38/55 (2006.01) A61K 9/20 (2006.01) A61K 31/33 (2006.01) A61K 31/395 (2006.01)

Patent

CA 2652620

The present invention provides stable pharmaceutical compositions comprising moisture sensitive drugs, in particular an angiotensin converting enzyme (ACE) inhibitor such as Cilazapril, as the active ingredient, and at least one pharmaceutical excipient, wherein the active pharmaceutical ingredient is wet granulated with a solution of at least one pharmaceutical excipient, and methods for preparing such stable pharmaceutical compositions.

La présente invention concerne des compositions pharmaceutiques stables contenant des médicaments sensibles à l'humidité, en particulier un inhibiteur de l'enzyme de conversion de l'angiotensine (ACE) tel que le Cilazapril, en tant que principe actif, et au moins un excipient pharmaceutique, l'ingrédient pharmaceutique actif étant préparé par granulation humide avec une solution d'au moins un excipient pharmaceutique. L'invention concerne également des procédés de préparation de telles compositions pharmaceutiques stables.

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