Method of formation of the shape-retentive aggregates of gel...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01)

Patent

CA 2583341

The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non~ covalent bond physical forces such as, without limitation, hydrophobic~hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape- retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.

L'invention concerne un procédé de formation d'agrégats de particules de gel à mémoire de forme, ces agrégats étant maintenus ensemble par des forces physiques de liaisons non covalentes telles que, entre autres, des interactions hydrophobes-hydrophiles et des liaisons hydrogène. Ce procédé consiste à introduire une suspension de particules de gel dans un liquide polaire, dans une concentration déterminée, les particules de gel présentant un potentiel zêta absolu, dans un milieu dans lequel le potentiel zêta absolu des particules de gel est réduit, ce qui entraîne la coalescence des particules de gel et produit l'agrégat à mémoire de forme selon l'invention. L'invention concerne également les utilisations de ce procédé de formation d'agrégats de particules de gel à mémoire de forme.

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