Fluorescence polarization assay related applications

Details Fluorescence polarization assay related applications Fluorescence polarization assay related applications

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2559723

Disclosed are methods and systems that use fluorescence polarization to identify compounds that have the ability to bind to, and/or modulate, the activity of the Receptor for Advanced Glycated Endproducts (RAGE). Compounds identified using the methods and systems of the present invention may comprise small organic molecule RAGE antagonists. The small organic molecule RAGE antagonists identified using the methods and systems of the present invention may be used to treat RAGE-mediated diseases, such as, but not limited to, diabetes or Alzheimer's disease.

L'invention concerne des procédés et des systèmes utilisant la polarisation de fluorescence permettant d'identifier des composés qui ont la capacité de se lier au récepteur de produits finaux glycatés avancés (RAGE), et/ou de moduler l'activité de ce récepteur. Les composés identifiés au moyen des procédés et des systèmes selon l'invention peuvent comprendre des antagonistes RAGE à petites molécules organiques. Les antagonistes RAGE à petites molécules organiques identifiés au moyen des procédés et des systèmes selon l'invention peuvent être utilisés pour le traitement de maladies associées à RAGE, telles que, toutefois, sans limitation, diabètes ou maladie d'Alzheimer.

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