A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/29 (2006.01) A61K 39/295 (2006.01)
Patent
CA 2352777
The present invention is related to the branch of medicine, particularly to the new formulations of vaccine antigens. The technical objective pursued with the present invention is, precisely, the development of formulations that are able to enhance the immune response to mucosally administered antigens, minimising the number of compounds in the formulation and generating strong mucosal and systemic responses through a synergic interaction between the antigens in the formulation. These formulations enable: a) to broaden the spectrum of the anti-hepatitis B immune response, containing as main compounds HBsAg and HBcAg, b) to enhance the response against HBsAg with a viral nucleocapsid c) to generate combined vaccines through the mucosal route with HBsAg as a central antigen. Stabilizers and preservatives can be introduced. The formulations of this invention can be applied in the pharmaceutical industry as human or veterinary vaccine formulations.
L'invention concerne des préparations susceptibles de stimuler la réponse immunitaire aux antigènes de l'hépatite B administrés par voie muqueuse. Ces préparations renferment a) un antigène de surface de l'hépatite B (Hbs Ag) et b) un antigène de la nucléocapside du virus de l'hépatite B (HBc Ag) permettant de générer des réponses muqueuses et systémiques au moyen d'une interaction synergique entre les antigènes de la préparation. Les préparations faisant l'objet de cette invention trouvent une application comme vaccins à usage médical et vétérinaire.
Aguilar Rubido Julio Cesar
Guillen Nieto Gerardo Enrique
Iglesias Perez Enrique
Muzio Gonzales Verena Lucilla
Palenzuela Gardon Daniel Octavio
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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