Neuropeptide y receptor y5 and nucleic acid sequence

Details Neuropeptide y receptor y5 and nucleic acid sequence Neuropeptide y receptor y5 and nucleic acid sequence

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12N 15/11 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250722

The present invention provides novel NPY/PYY receptor proteins and the nucleic acid sequence encoding them. The invention is directed to the isolation, characterization, and pharmacological use of these receptors and nucleic acids. In particular, this invention provides human and rat NPY/PYY receptors (which we call the NPY Y5 receptor) and nucleic acids. Also provided are recombinant expression constructs useful for transfecting cells and expressing the protein in vitro and in vivo. The invention further provides methods for detecting expression levels of the protein as well as methods for screening for receptor antagonists and agonists to be used for the treatment of obesity or anorexia, respectively.

L'invention concerne de nouvelles protéines de récepteurs NPY/PYY et la séquence d'acide nucléique les codant. L'invention concerne l'isolement, la caractérisation et l'utilisation pharmacologique de ces récepteurs et acides nucléiques. En particulier cette invention concerne des récepteurs NPY/PYY de l'homme et du rat (appelés le récepteur NPY Y5) et les acides nucléiques. L'invention concerne également des produits de construction d'expression recombinants utiles pour la transfection de cellules et l'expression de la protéine in vitro et in vivo. L'invention décrit également des méthodes de détection de niveaux d'expression de la protéine ainsi que des méthodes de recherche d'antagonistes et d'agonistes du récepteur à utiliser pour le traitement de l'obésité ou de l'anorexie, respectivement.

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