Chewable drug-delivery composition

Details Chewable drug-delivery composition Chewable drug-delivery composition

A - Human Necessities

61

K

A61K 9/42 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2103443

A non-aqueous, chewable composition for oral delivery of unpalatable drugs is provided. The composition contains the drug intimately dispersed or dissolved in a pharmaceutically acceptable lipid that is solid at room temperatures. The composition also has a matrix that contains a granulating agent for the total composition and a rapid dispersal agent and optionally additives such as buffering agents, flavoring agents, surfactants, and the like. Methods for the preparation of the chewable compositions are also provided.

Composition à croquer, non aqueuse, pour administration orale de médicaments désagréables au goût. La composition contient le médicament étroitement dispersé ou dissout dans un lipide acceptable du point de vue pharmaceutique, lipide qui est solide à la température de la pièce. Elle comprend également une matrice contenant un agent de granulation pour toute la composition, un agent dispersant à action rapide et, au choix, des additifs comme des tampons, des aromatisants, des surfactants et d'autres produits semblables. Les méthodes de préparation des compositions à croquer sont également divulguées.

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