Method of drug formulation based on increasing the affinity...

Details Method of drug formulation based on increasing the affinity... Method of drug formulation based on increasing the affinity...

A - Human Necessities

61

K

A61K 9/16 (2006.01)

Patent

CA 2621806

Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.

L'invention concerne des méthodes permettant d'enrober des microparticules cristallines d'un principe actif en modifiant les propriétés de surface des microparticules afin de favoriser une fixation adéquate du principe actif sur la microparticules. Les types de propriétés de surface modifiées par les procédés décrits comprennent les propriétés électrostatiques, les propriétés hydrophobes, et les propriétés de fixation de l'hydrogène.

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