Gene sequences of rubella virus associated with attenuation

Details Gene sequences of rubella virus associated with attenuation Gene sequences of rubella virus associated with attenuation

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/20 (2006.01) A61K 48/00 (2006.01) C07K 14/19 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2298070

The complete sequence of the Cendehill rubella strain is provided, including infectious cDNA clones derived therefrom. Portions of the Cendehill genome responsible for decreased arthritogenicity and immunogenicity are identified. Modified rubella cDNA, RNA and virus is provided incorporating Cendehill and non-Cendehill sequences.

L'invention concerne la séquence complète de la souche rubéolique de Cendehill, y compris des clones infectieux de l'ADN complémentaire qui en sont dérivés. Des parties du génome de Cendehill responsables de la diminution de l'arthritogénicité et de l'immunogénicité ont été identifiés. L'invention concerne également un ADN complémentaire, un ARN et un virus rubéoliques modifiés comprenant des séquences de la souche rubéolique de Cendehill ou d'autres souches.

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