Akt compositions for enhancing survival of cells

Details Akt compositions for enhancing survival of cells Akt compositions for enhancing survival of cells

A - Human Necessities

61

K

A61K 38/45 (2006.01) A01N 1/02 (2006.01) A61K 38/19 (2006.01) A61K 38/30 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2335391

This invention relates to methods and compositions for the treatment of apoptotic cell-death. In particular the invention relates to Akt molecules and their use in inhibiting apoptotic cell-death in cardiomyocytes, skeletal myocytes and/or vascular endothelial cells. In view of these discoveries, Akt molecules can be used to inhibit apoptotic cell-death of any of the foregoing cells, and in particular, to treat conditions (e.g., myocardial infarction) that result in increased apoptotic cell-death of cardiomyocytes, skeletal myocytes and/or vascular endothelial cells.

L'invention concerne des procédés et des compositions pour le traitement de la mort cellulaire apoptotique. L'invention concerne en particulier des molécules Akt et leur utilisation dans l'inhibition de la mort cellulaire apoptotique dans les cardiomyocytes, les myocytes squelettiques ou les cellules endothéliales vasculaires. On peut utiliser les molécules Akt selon l'invention pour inhiber la mort cellulaire apoptotique de n'importe quelles cellules précédentes et, en particulier, pour traiter les conditions (infarctus du myocarde, par exemple) qui entraînent l'augmentation de la mort cellulaire apoptotique des cardiomyocytes, des myocytes squelettiques ou des cellules endothéliales vasculaires.

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