Addition of transgenes into adenoviral vectors

Details Addition of transgenes into adenoviral vectors Addition of transgenes into adenoviral vectors

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 1/10 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2574698

Adenoviral vectors are provided that contain a transgene inserted in the viral genome at a novel site such that one or more of native processing, regulatory signals or heterologous transcription signals such as branch point sites, splice acceptor sites, internal ribosome entry sites, self-processing cleavage sites and/or polyA signals contribute to transgene expression.

La présente invention a trait à des vecteurs adénoviraux contenant un transgène inséré dans le génome viral à un nouveau site de sorte qu'un ou plusieurs signaux natifs de traitement régulateurs ou des signaux de transcription hétérologues tels que des sites de point de branchement, des sites accepteurs d'épissage, des sites d'entrée internes du ribosome, des sites de clivage d'auto-traitement et/ou des signaux polyA contribuent à l'expression transgénique.

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