Molecular hepatotoxicology modeling

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2471661

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in liver tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by liver toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

L'invention concerne l'élucidation de changements globaux affectant l'expression génique et l'identification de marqueurs de toxicité dans des tissus ou des cellules hépatiques exposés à une toxine connue. Les gènes peuvent être utilisés en tant que marqueurs de toxicité dans le criblage de principe actif et dans des tests de toxicité. L'invention concerne aussi une base de données de gènes, caractérisés par l'expression hépatique différentielle induite par toxine, conçue pour être utilisée avec des micromatrices et d'autres sondes en phase solide.

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