Use of quinones in the treatment of cancer or aids

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 31/04 (2006.01) A61K 31/12 (2006.01) A61K 31/135 (2006.01) A61K 31/15 (2006.01) A61K 31/16 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2104009

2104009 9214454 PCTABS00015 The invention relates to a pharmaceutical composition comprising at least one quinone and to its use in the treatment of disease, especially cancer and virus infections. The composition of the invention comprises at least one quinone dissolved or dispersed in a liquid diluent or carrier at a concentration of about 10-3 moles/litre or below, preferably down to 10-18 moles/litre. In the composition the at least one quinone is preferably: an anthraquinone glycoside, more preferably carminic acid. A compound of formula (I) wherein R1 is hydrogen, a sugar e.g. -C6H11O5, hydroxy, (a) in which R5 is -CH2NHAc, -CH2OH, -CH(NH2)CO2H or -CH2NH2; R2 is methyl or -CO2H; R3 is hydrogen, -NH2 or -SO3X in which X is H, Na or K; and R4 is hydrogen or hydroxy. Quinhydrone of formula (II); tetrahydroxyquinone of formula (III).

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