Genes from a gene cluster

Details Genes from a gene cluster Genes from a gene cluster

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07H 21/00 (2006.01) C07K 14/385 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12P 17/18 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2342397

ML-236B is an inhibitor of HMG-CoA reductase and useful in preparing another such inhibitor, pravastatin. The preparation of ML-236B using an ML-236B-producing microorganism is enhanced using a polynucleotide encoding a gene related to the polyketide synthase cluster occuring in such a microorganism.

ML-236B est un inhibiteur de la HMG-CoA réductase et est utile pour préparer un autre inhibiteur de la même famille, soit la pravastatine. La préparation de ML-236B à l'aide d'un micro-organisme produisant ML-236B est améliorée par le recours à un polynucléotide codant un gène apparenté au groupe des polyketide synthases présentes dans ces microorganismes.

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