Tetrapeptides deriving from dalbaheptide antibiotics

Details Tetrapeptides deriving from dalbaheptide antibiotics Tetrapeptides deriving from dalbaheptide antibiotics

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) C07K 5/107 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2098098

Tetrapeptides of general formula (I) deriving from dalbaheptide antibiotics wherein: W and Z represent the relative por- tions of the aglycon of an antibiotic of the dalbaheptide group (aglucodalbaheptides); Y represents a carboxyacid group or a functional derivative of said carboxyacid group; R and R0 each independently represent amino or a protected amino group; R1 represents hydrogen or a protecting group of the carboxyacid function; and its salts with acids and bases as well as its inner salts. A process for producing the tetrapeptides of formula (I) from the corresponding dalbaheptides and aglucodal- baheptides.

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