Tricyclic compounds useful for inhibition of g-protein...

Details Tricyclic compounds useful for inhibition of g-protein... Tricyclic compounds useful for inhibition of g-protein...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) C07D 413/14 (2006.01) C07F 9/572 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2264569

Compounds of formula (1.0), their use as farnesyl transferase protein inhibitors and pharmaceutical compositions containing them are disclosed, especially compounds of formula (1.5A) wherein R1, R2 and R3 are halo, A and B are each H2, and R is as defined in the specification.

L'invention porte sur des composés de formule (1.0), sur leur utilisation comme inhibiteur de la farnésyl transférase et sur des préparations pharmaceutiques les contenant, et en particulier sur des composés de formule (1.5A) dans laquelle R?1¿, R?2¿ et R?3¿ sont halo, A et B sont chacun H¿2?, et R est défini dans la description.

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