Oral solid dose vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/39 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2424160

The present invention relates to novel vaccine formulations suitable for oral administration. The vaccine formulations are in a solid form comprising antigen and suitable excipient, which after insertion into the mouth, rapidly dissolve in saliva, thereby releasing the vaccine into the mouth. Specifically, the solid form may consist of a cake of vaccine which is formed from a liquid solution or suspension by sublimation, preferably sublimation by lyophilisation. Preferred vaccines are those containing antigens which are derived from pathogens that normally infect or invade the host through a mucosal membrane, or those vaccines that further comprises an antacid. Particularly preferred vaccines are combination vaccines that comprise more than one antigen, and more preferably when the antigens are from more than one pathogen.

L'invention concerne de nouvelles formulations de vaccin pouvant être administrées par voie orale. Ces formulations de vaccin se présentent sous une forme solide contenant un antigène et des excipients appropriés, qui, après introduction dans la bouche, se dissolvent rapidement dans la salive, ce qui permet de libérer le vaccin dans la bouche. Cette forme solide peut, plus particulièrement, être constituée par un pain de vaccin obtenu à partir d'une solution ou d'une suspension liquide par sublimation, de préférence, sublimation par lyophilisation. Les vaccins préférés sont ceux qui contiennent des antigènes consistant en des pathogènes, ou provenant de pathogènes qui infectent ou envahissent habituellement le récepteur à travers la membrane de la muqueuse, ou les vaccins qui contiennent, de plus, une base. Dans un mode de réalisation préféré, ces vaccins sont des vaccins combinés contenant plus d'un antigène et, de préférence, dans lesquels les antigènes proviennent de plus d'un pathogène.

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