Pharmaceutival preparations comprising corticosteroids and...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2428189

The invention consists of a stable preparation of a combination drug, comprising of an anti-inflammatory agent and an anti-infective agent. The anti- inflammatory agent in this invention is a corticosteroid, and the anti- infective agent is a derivative of quinolone, amino-glycoside or their pharmaceutically acceptable salts. The combination drug essentially comprises of i) an anti-inflammatory agent which is a corticosteroid, ii) an anti- infective agent selected from the group comprising of derivatives of quinolone, aminoglycoside and their pharmaceutically acceptable salts; iii) a complexation enhancing polymer; iv) a solubiliser exhibiting an inclusion phenomenon, along with pharmaceutically acceptable excipients with a suitable carrier system.

L'invention concerne une préparation stable d'un médicament combiné, comprenant un agent anti-inflammatoire et un agent anti-infectieux. Dans cette invention, l'agent anti-inflammatoire est un corticostéroïde, et l'agent anti-infectieux est un dérivé de quinolone, un aminoglycoside ou un de leurs sels acceptables sur le plan pharmaceutique. Le médicament combiné comprend essentiellement i) un agent anti-inflammatoire qui est un corticostéroïde, ii) un agent anti-infectieux sélectionné parmi le groupe comprenant de dérivés de quinolone, des aminoglycosides et leurs sels acceptables sur le plan pharmaceutique, iii) un polymère améliorant la complexation, iv) un agent de solubilisation possédant la propriété de réaliser un phénomène d'inclusion, des excipients acceptable sur le plan pharmaceutique et un système de support adéquat.

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