Novel farnesyl protein transferase inhibitors and their use...

Details Novel farnesyl protein transferase inhibitors and their use... Novel farnesyl protein transferase inhibitors and their use...

C - Chemistry, Metallurgy

07

D

C07D 491/044 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2590979

Disclosed are compounds of the formula: wherein R8 represents a cyclic and acyclic moiety to which is bound an imidazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

L'invention concerne des composés de formule générale (I) dans laquelle R8 représente un fragment cyclique et acyclique auquel est lié un groupe imidazolylalkyle ; R9 représente un groupe carbamate, urée, amide ou sulfonamide ; la signification des autres composants étant indiquée dans la description. L'invention concerne également un procédé de traitement du cancer et un procédé permettant d'inhiber la farnésyl protéine transférase au moyen desdits composés.

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