Solid pharmaceutical dosage form

Details Solid pharmaceutical dosage form Solid pharmaceutical dosage form

A - Human Necessities

61

K

A61K 31/427 (2006.01) A61K 9/10 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2689639

A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50 °C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.

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