C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2347120
Disclosed are complexes of the NlK1 protein and proteins identified as interacting with the NlK1 protein (NlK1 protein-IPs). The NlK-1 interacting proteins include TrkA, protein phosphatase 1.alpha., 14-3-3.epsilon., .alpha.- tropomyosin, vimentin, p0071, Ini-1, and newly described proteins named IP-1, IP-2, IP-3, IP-4, and IP-5. Also described are derivatives, fragments analogs and homologs of these proteins. Methods of screening these complexes for efficacy in treating and/or preventing various diseases and disorders, particularly, neoplasia, neurodegenerative disease, hypertrophic cardiomyopathy, viral infections and metabolic diseases and disorders are also disclosed.
La présente invention concerne des complexes de la protéine NlK1 et des protéines identifiées pour leur interaction avec la protéine NlK1 (protéine d'interaction IP avec protéine NlK1). Les protéines NlK1 d'interaction comprennent TrKA, protéine phosphatase 1.alpha., 14-3-3.epsilon., .alpha.-tropomyosine, vimentine, p0071, Ini-1, et des protéines récemment décrites appelées IP-1, IP-2, IP-3, IP-4, et IP-5. Par ailleurs, cette invention concerne des dérivés, des homologues et des analogues de fragments de ces protéines. En outre, l'invention concerne des procédés de criblage de ces complexes permettant de traiter et/ou de prévenir efficacement différents troubles et maladies, en particulier la néoplasie, les maladies neurodégénératives, la cardiomyopathie hypertrophique, les infections virales, ainsi que les maladies et les troubles métaboliques.
Nandabalan Krishnan
Schulz Vincent P.
Yang Meijia
Curagen Corporation
Ridout & Maybee Llp
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