Hollow fiber co-flow filtration device

Details Hollow fiber co-flow filtration device Hollow fiber co-flow filtration device

B - Operations, Transporting

01

D

B01D 63/02 (2006.01) B01D 61/14 (2006.01) B01D 63/10 (2006.01) B01D 69/10 (2006.01)

Patent

CA 2298602

The present invention is directed to hollow fiber membrane filtration modules and processes useful for improved tangential flow filtration-mediated purification and separation of molecules from mixtures of molecules, wherein those molecules may be of biological interest. The hollow fiber membrane filtration modules of the present invention are such that the transmembrane pressure along the entire length of the hollow fibers is substantially constant, thereby providing enhanced filtration capabilities, especially for large-scale recombinant protein purification. The hollow fiber filtration modules of the present invention may be employed either with or without co-current recirculation of the filtrate.

La présente invention porte sur des modules et des processus de filtration sur membrane à fibres creuses utilisés dans la purification et la séparation améliorées, induites par une filtration à écoulement tangentiel, de molécules provenant de mélanges de molécules et pouvant avoir un intérêt biologique. La conception des modules de filtration sur membrane à fibres creuses de cette invention permet que la pression transmembranaire s'exerçant sur toute la longueur des fibres creuses soit pratiquement constante, ce qui améliore les capacités de filtration, notamment dans la purification à grande échelle de protéines de recombinaison. Les modules de filtration à fibres creuses de cette invention peuvent être utilisés avec ou sans recirculation du filtrat par co-écoulement.

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