C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01) A61K 31/557 (2006.01) A61K 31/5575 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2180008
The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3- hydroxycyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
L'invention concerne les acides 7-[5-hydroxy-2-(hydroxyhydrocarbyle ou hydroxyhydrocarbyle substitué par un hétéroatome)-3-hydroxycyclopentyl(ényl)] heptanoïques ou hepténoïques, ainsi que les dérivés desdits acides, où un ou plusieurs desdits groupes hydroxy sont remplacés par un groupe éther. Les composés de la présente invention sont des hypotenseurs oculaires puissants et ils sont particulièrement utiles pour traiter le glaucome.
Allergan
Allergan Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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