A process for producing an iron-dextran compound

A - Human Necessities – 61 – K

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A61K 31/715 (2006.01) A61K 31/295 (2006.01) A61K 31/721 (2006.01) A61K 47/48 (2006.01) C08B 37/00 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2332882

In a process for producing an iron-dextran compound for use in parenteral treatment of iron-deficiency in humans or animals a stable compound of desired relatively low molecular weight is obtained by using first hydrogenation and then oxidation to convert reducing terminal groups on the dextran molecules before reaction with the iron. By varying the ratio of hydrogenated groups to oxygenated groups the average molecular weight of the resulting iron-dextran compound can be varied.

La présente invention concerne un procédé de production d'un composé de fer dextran destiné au traitement parentéral de l'anémie ferriprive chez l'homme ou les animaux. Pour réaliser à cette fin un composé stable d'une masse moléculaire intentionnellement relativement basse, on commence par réaliser une hydrogénation suivie d'une oxydation de façon à convertir les groupes à terminaisons réductrices des molécules de dextran avant leur réaction avec le fer. Pour faire varier la masse moléculaire moyenne du composé fer dextran résultant, on intervient au niveau du rapport entre groupes hydrogénés et groupes oxygénés.

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