C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/47 (2006.01) C07D 401/04 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2293553
Novel aminooxyamide tricyclic compounds of formula (1.0): (see formula 1.0) and pharmaceutical compositions containing them are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
La présente invention concerne de nouveaux composés tricycliques aminooxyamide et des compositions pharmaceutiques acceptables qui sont des inhibiteurs de l'enzyme farsényl protéine transférase. La présente invention concerne également un procédé d'inhibition de la fonction Ras et donc d'inhibition de la croissance anormale des cellules. Le procédé consiste à administrer le nouveau composé tricyclique aminooxyamide à un système biologique. Ce procédé permet d'inhiber, en particulier, la croissance anormale des cellules chez des mammifères tels que l'homme.
Doll Ronald J.
Lalwani Tarik
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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