Pim-3 kinase as a target for type 2 diabetes mellitus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) A61K 38/43 (2006.01) A61K 38/45 (2006.01) A61P 3/10 (2006.01) C12N 1/21 (2006.01) C12N 9/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2473566

The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3, activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

La présente invention concerne des molécules d'acide nucléique isolées et des cellules hôtes comportant lesdites molécules. Elle concerne en outre un polypeptide ayant une activité PIM-3 et possédant une séquence définie d'acides aminés, ainsi que l'utilisation de PIM-3 en tant qu'agent de criblage pour identifier des médicaments contre le diabète de type 2 et pour préparer un remède destiné à traiter la résistance à l'insuline ou diabète de type 2.

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