Serine protease variants having amino acid deletions and...

Details Serine protease variants having amino acid deletions and... Serine protease variants having amino acid deletions and...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 8/02 (2006.01) A61K 8/66 (2006.01) A61Q 19/00 (2006.01) A61Q 19/10 (2006.01) C12N 9/54 (2006.01)

Patent

CA 2324422

The present invention relates to variants of serine proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a deletion and, optionally, a substitution of one or more specifically identified positions corresponding to subtilisin BPN'. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.

Cette invention se rapporte à des variants de sérine-protéases ayant une immunogénicité inférieure à celle des protéases du type sauvage correspondantes. Cette invention se rapporte plus particulièrement à des variants ayant une séquence d'acides aminés modifiée par rapport à une séquence d'acides aminés de type sauvage, cette séquence d'acides aminés modifiée comportant une délétion et, éventuellement, une substitution d'une ou de plusieurs positions spécifiquement identifiées correspondant à la subtilisine BPN'. Cette invention se rapporte en outre à des gènes mutants codant ces variants et à des compositions de produits de nettoyage et de produits de soins personnels comprenant ces variants.

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