Inhibitors of prenyl-protein transferases

Details Inhibitors of prenyl-protein transferases Inhibitors of prenyl-protein transferases

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 27/02 (2006.01) A61P 31/14 (2006.01) A61P 35/00 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2362495

The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases. In particular, the invention relates to prenyl- protein transferase inhibitors which are efficacious in vivo as inhibitors of geranylgeranyl-protein transferase type I (GGTase-I) and that inhibit the cellular processing of both the H-Ras protein and the K4B-Ras protein. Such therapeutic compounds are useful in the treatment of cancer.

La présente invention concerne des composés contenant de la pipérazine et inhibant des prényl-protéine transférases. L'invention concerne en particulier des inhibiteurs de prényl-protéine transférases efficaces in vivo comme inhibiteurs de géranylgéranyl-protéine transférases de type I (GGTase-I) et inhibant le traitement cellulaire de la protéine H-Ras et de la protéine K4B-Ras. Ces composés thérapeutiques s'utilisent pour le traitement du cancer.

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