Proteins for inhibiting adhesion of platelets to collagen

Details Proteins for inhibiting adhesion of platelets to collagen Proteins for inhibiting adhesion of platelets to collagen

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 1/36 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2084834

1053H/2042A 18143 TITLE OF THE INVENTION PROTEINS FOR INHIBITING ADHESION OF PLATELETS TO COLLAGEN ABSTRACT OF THE DISCLOSURE The invention comprises proteinaceous substances isolated from crude Ornithodoros moubata extract which inhibit adhesion of platelets to collagen. These substances do not inhibit platelet adhesion to fibrinogen, and are therefore particularly useful for inhibiting adhesion of platelets to collagen when simultaneous inhibition of platelet adhesion to fibrinogen is undesired. They are particularly useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.

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