Targeted drug delivery methods

Details Targeted drug delivery methods Targeted drug delivery methods

A - Human Necessities

61

K

A61K 51/10 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 41/00 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61K 51/12 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2476888

The identification of radiation-inducible genes by isolating RNA from irradiated cell cultures and then hybridizing the isolated RNA to nucleic acid sequences from an organism of interest (e.g. mammals such as mice and human beings); a method for x-ray guided drug delivery using a targeting ligand that specifically recognizes a radiation-inducible RNA target molecule; and magnetic dispersion of an active agent, such as the dispersion of a genetic construct within a tumor.

L'invention concerne un procédé d'identification de gènes pouvant être induits par rayonnement consistant en l'isolation de l'ARN de cultures de cellules irradiées et en l'hybridation postérieure entre l'ARN isolé et des séquences d'acides nucléiques d'un organisme d'intérêt (p. ex. des mammifères tels que des souris ou des êtres humains) ; un procédé d'administration d'un médicament guidé par rayons X au moyen d'un ligand de ciblage qui reconnaît particulièrement une molécule cible d'ARN pouvant être induite par rayonnement ; et la dispersion magnétique d'un agent actif, tel que la dispersion d'un produit de synthèse génétique à l'intérieur d'une tumeur.

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