C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 38/07 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/735 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2172392
The present invention relates, in general, to methods of treating diseases resulting from interactions between immune complexes and Fc receptors. In particular, the present invention relates to methods of modulating the clearance of antibody-coated cells from the circulation by inhibiting phagocytosis and to methods of modulating the interaction of immune complexes with tissue Fc receptors. Further, the invention relates to methods of modulating the activation of immunological processes mediated by Fc receptor activation resulting from antibody-antigen/receptor interaction.
L'invention porte en général sur des méthodes de traitement de maladies résultant d'interactions entre des complexes immunitaires et des récepteurs du fragment Fc, et en particulier sur des méthodes de modulation du retrait, de la circulation, de cellules enrobées d'anticorps, par inhibition de la phagocytose, et sur des méthodes de modulation de l'interaction de complexes immunitaires avec les récepteurs tissulaires du fragment FC. L'invention porte également sur des méthodes de modulation de l'activation de processus immunologiques induits par l'activation des récepteurs du fragment Fc résultant de l'interaction anticorps-antigène/récepteur.
Park Jong-Gu
Schreiber Alan D.
Goudreau Gage Dubuc
University Of Pennsylvania
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