C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/245 (2006.01) C07K 14/03 (2006.01) C07K 14/125 (2006.01) C12N 7/01 (2006.01) C12N 15/53 (2006.01) C12N 15/869 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2055489
(57) Abstract The recombinant virus chosen from the turkey herpesvirus (HVT), Aujeszky's disease virus (PRV), infectious bovine rhinot- racheitis virus (BHV), feline infectious rhinotracheitis virus (FHV), equine rhinopneumonia virus (EHV), canine herpesvirus (CHV), duck herpesvirus, human simplex herpesvirus (HSV), varicella virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), comprises at least one heterologous gene, coding particularly for a viral, bacterial or parasitic immunogen inserted in the region of the genome of the said virus corresponding to the gene of the small sub-unit RR2 of ribonucleotide reductase so that it may be expressed. The method for preparing a virus of this type involves inserting the heterologous gene into the said region of the genome, particularly arter partial or total deletion of this region. The recombinant virus obtained may be used particularly for preparing living vaccines. The small sub-unit of the ribonucleotide reductase of the turkey herpesvirus (HVT) has been sequenced.
Kohen Gilla
Rey-Sene-Longe Arielle
Fetherstonhaugh & Co.
Merial Societe Par Actions Simplifiee
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