A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01)
Patent
CA 2720363
The present invention features compositions and methods that make use of complexes comprising one or more in-hibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, in delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.
La présente invention concerne des compositions et des procédés recourant à des complexes comprenant un ou plusieurs acides nucléiques inhibiteurs et un polypeptide ciblant constitué d'un ligand de récepteur superficiel de cellule. Ces compositions, qui conviennent à des procédés consistant à faire taire l'expression génique dans une cellule, peuvent s'utiliser, d'une part pour fournir des agents à une cellule cible, et d'autre part pour traiter ou prévenir une maladie ou un trouble chez un sujet.
Arya Bira
Espinoza Juan
Olkhanud Purevdorj
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Government Of The United States Of America As Represented By The Secret Ary Of The Department Of Health And
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