3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives

Details 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2048959

This invention relates to 3-(1,2-benzisoxazol-3-yl)-4- pyridinamines of the formula (see formula I) where R1 is hydrogen, loweralkyl, arylalkyl or aryl; R2 is hydrogen, loweralkyl or arylalkyl, X is hydrogen, halogen, nitro or amino; or the pharmaceutically acceptable addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention are useful as analgesics, for alleviating various memory dysfunctions characterized by a decreased cholinergic function, as cognition enhancers in the treatment of senile dementia such as Alzheimer's disease and as topical antiinflammatory agents for the treatment of various dermatoses.

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