C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 225/20 (2006.01) A61K 31/135 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) A61P 13/12 (2006.01)
Patent
CA 2594388
The invention relates to novel squaric acid compounds of formula (I) wherein R, Rl, R1', R2 and X have the designations cited in patent claim (1). Said compounds are SGK inhibitors and can be used to treat SGK-related diseases and illnesses such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonal hypertonia, cardiovascular diseases and kidney diseases, and generally all types of fibroses and inflammatory processes.
L'invention concerne de nouveaux composés d'acide quadratique représentés par la formule (I) dans laquelle R, R1, R1', R2 et X ont les significations données dans la revendication (1). Lesdits composés sont des inhibiteurs de SGK et peuvent être employés dans le traitement de maladies et troubles associés à SGK, tels que le diabète, la boulimie, le syndrome métabolique (dislipidémie), l'hypertonie systémique et pulmonaire, des maladies cardiovasculaires et des maladies rénales, et en général dans toute sorte de fibroses et processus inflammatoires.
Beier Norbert
Dorsch Dieter
Gericke Rolf
Klein Markus
Lang Florian
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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