Method for percutaneous delivery of ibuprofen using...

Details Method for percutaneous delivery of ibuprofen using... Method for percutaneous delivery of ibuprofen using...

A - Human Necessities

61

K

167/159, 167/262

A61K 31/19 (2006.01) A61K 9/107 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2033499

An ibuprofen containing hydroalcoholic gel of pH 3.5 to 6.0 for topically treating inflammation or pain comprising an effective amount of ibuprofen; 40 to 60% alcohol, e.g. ethanol or isopropyl alcohol; 0-20% of a non-volatile solvent, e.g. propylene glycol; 2.0 to 5.0% gelling agents, e.g. 2.5% hydroxypropyl cellulose or 4.0% polyacrylic acid polymer; sufficient base, e.g. triethanolamine, to adjust the pH to between 3.5 and 6.0; and water; methods for delivering ibuprofen through the skin to treat inflammation or pain using the hydroalcoholic gel; and use of substantially pure S-ibuprofen to topically treat such inflammation or pain.

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