Delivering functional nucleic acids to mammalian cells via...

Details Delivering functional nucleic acids to mammalian cells via... Delivering functional nucleic acids to mammalian cells via...

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2577938

Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.

Minicellules intactes dérivées par bactéries contenant des acides nucléiques fonctionnels ou des plasmides codant des acides nucléiques fonctionnels pouvant réduire, dans des cellules ciblées de mammifères, la résistance aux médicaments, la résistance à l'apoptose, et la capacité néoplasique respectivement. La méthodologie utilisant de minicellules pour administrer des acides nucléiques fonctionnels, ciblant les transcriptions de protéines contribuant à la résistance aux médicaments ou à la résistance à l'apoptose, entre autres, peuvent être combinées à la chimiothérapie pour augmenter l'efficacité de cette dernière.

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