Chiral intermediates for the preparation of antidiabetics...

Details Chiral intermediates for the preparation of antidiabetics... Chiral intermediates for the preparation of antidiabetics...

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2111446

Two novel optically pure intermediates, (R)-4-(2-bromo-1-hydroxyethyl)-2-trifluoro(-)methylthiazole and (5)-4-oxiranyl- 2-trifluoromethyltiazole, which have utility in the synthesis of a potent class of antidiabetic agents. The invention also embraces an enantioselective reduction process for their preparation.

Deux nouveaux intermédiaires optiquement purs, (R)-4-(2-bromo-1-hydroxyéthyl)-2-trifluoro(-)méthylthiazole et (5)-4-oxyranyl-2-trifluorométhyltiazole, qui sont utiles dans la synthèse d'une classe d'agents antidiabétiques puissants. L'invention concerne également un procédé de réduction énantiosélective pour la préparation de ces intermédiaires.

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