Antibody-based therapeutics with enhanced adcc activity

Details Antibody-based therapeutics with enhanced adcc activity Antibody-based therapeutics with enhanced adcc activity

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2626556

Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose- type N/-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.

L'invention porte sur des méthodes d'élaboration de thérapies à base d'anticorps à activité ADCC renforcée laquelle est attribuée aux N/-glycans de type oligomannose des anticorps et aux protéines de fusion de l'invention. L'invention porte également sur des méthodes d'utilisation desdites thérapies pour la destruction ciblée de cellules de mammifères, y compris des méthodes de traitement de cancers, de maladies auto-immunes, et autres.

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