Synthesis of bis-indolylmaleimides

Details Synthesis of bis-indolylmaleimides Synthesis of bis-indolylmaleimides

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 31/40 (2006.01) C07D 209/42 (2006.01) C07D 245/04 (2006.01) C07D 255/04 (2006.01) C07D 273/02 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 487/06 (2006.01) C07D 487/08 (2006.01) C07D 487/12 (2006.01) C07D 487/18 (2006.01) C07D 491/12 (2006.01) C07D 491/22 (2006.01) C07D 498/12 (2006.01) C07D 498/16 (2006.01) C07D 498/18 (2006.01) C07D 498/22 (2006.01)

Patent

CA 2216633

The present invention provides an efficient process of reacting a bis-indolyl acid of Formula (II), wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of Formula (III). Compounds of Formula (III) are readily converted to the bis- indolylmaleimides.

La présente invention concerne un procédé efficace de réaction d'un acide de bis-indolyle de la formule (II), dans laquelle R?1¿ représente de l'hydrogène ou un alkyle C¿1?-C¿4? et R, X et Y sont d'éventuelles substitutions, ceci afin de produire un acide bis-indolyloxallique la formule (III). Les composés correspondant à la formule (III) peuvent être facilement transformés en bis-indolylmaléimides.

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