C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 14/40 (2006.01) C07K 16/14 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2347983
The infection of a mammalian host by a microorganism Candida albicans can be prevented or treated through the administration the substrate for transglutaminases Hwp or antibodies against this substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
Il est possible d'empêcher ou de traiter l'infection d'un mammifère hôte par un micro-organisme, par administration de substrats pour transglutaminases ou d'anticorps contre ces substrats inhibant l'interaction induite par la transglutaminase dudit micro-organisme avec un mammifère hôte. Ces composés peuvent être utilisés pour identifier, prévenir ou traiter une infection microbienne chez des mammifères hôtes, tels que des humains présentant un déficit immunitaire ou immunosuppressifs, par exemple, ceux atteint du SIDA ou ceux ayant subi une transplantation ou une thérapie anti-cancer.
Bradway Steven
Sundstrom Paula
Smart & Biggar
Sundstrom Paula
Trustees Of Dartmouth College
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