Phosphonosuccinic acid derivatives, processes for their...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/547 (2006.01) C07F 9/553 (2006.01) C07F 9/572 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2125867

-34- Summary Compounds of the formula I Image (I) in which R signifies a possibly substituted amino group of the general formula -NR1R2, whereby, independently of one another, R1 and R2 each signify hydrogen, lower alkyl, lower alkenyl or lower alkynyl or R represents a saturated, unsaturated or aromatic heterocyclic ring which can possibly be substituted once or twice by lower alkyl or halogen, alk signifies a valency bond, a methylene, a saturated or unsaturated, straight-chained or branched alkylene chain with 2 - 6 carbon atoms and R3, R4 and R5, in each case independently of one another, signify hydrogen, lower alkyl or benzyl, as well as their pharma- cologically acceptable salts and enantiomers, whereby, for the case that R3 = R4 = R5 = CH3 and alk signifies a valency bond, R cannot be the dimethylamino group, processes for their preparation and medicaments which contain these compounds for the treatment of calcium metabolism diseases.

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