Vectors and methods for gene transfer to cells

Details Vectors and methods for gene transfer to cells Vectors and methods for gene transfer to cells

C - Chemistry, Metallurgy

12

N

C12N 15/34 (2006.01) C07K 14/075 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2236912

The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus coat protein according to the invention is able to direct entry into cells of a vector comprising the coat protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus coat protein rather than the chimeric adenovirus coat protein. The chimeric coat protein preferably is a fiber, hexon, or penton protein. The present invention also provides an adenoviral vector that comprises the chimeric adenovirus coat protein, as well as methods of constructing and using such a vector.

Cette invention concerne une protéine d'enveloppe d'adénovirus chimérique qui diffère de la protéine d'enveloppe du type sauvage par l'introduction d'une séquence d'acides aminés non native. La protéine d'enveloppe d'adénovirus chimérique de cette invention est capable de diriger l'entrée dans des cellules d'un vecteur comprenant la protéine d'enveloppe, ce vecteur étant plus efficace qu'un vecteur similaire comprenant une protéine d'enveloppe d'adénovirus du type sauvage plutôt que la protéine d'enveloppe d'adénovirus chimérique. La protéine d'enveloppe chimérique est de préférence une fibre, un hexon ou une protéine pentonique. Cette invention concerne également un vecteur adénoviral qui comprend la protéine d'enveloppe d'adénovirus chimérique, ainsi que des procédés de construction et d'utilisation dudit vecteur.

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